112 - Menopause
A new year and a new beginning. Special guest co-host Pedro Mendes joins Dr. Chris Labos to answer a viewer question about menopause.
Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE Email us your questions at [email protected]. Assistant researcher: Aigul Zaripova, MD
Editor: Robyn Flynn
Theme music: “Fall of the Ocean Queen“ by Joseph Hackl
Rod of Asclepius designed by Kamil J. Przybos Chris’ book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-
cancer Obviously, I’m not your doctor (probably). This podcast is not medical advice for you; it is what
we call information. References: Geographic variability of menopausal symptoms
1) Nappi RE et al. Global cross-sectional survey of women with vasomotor symptoms
associated with menopause: prevalence and quality of life burden. Menopause. 2021 May
24;28(8):875-882. doi: 10.1097/GME.0000000000001793.
2) Nappi RE, et al. Prevalence and quality-of-life burden of vasomotor symptoms associated
with menopause: A European cross-sectional survey. Maturitas. 2023 Jan;167:66-74. doi:
10.1016/j.maturitas.2022.09.006.
What’s the normal duration of symptoms
3) Avis NE, et al. Study of Women\'s Health Across the Nation. Duration of menopausal
vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015 Apr;175(4):531-9.
doi: 10.1001/jamainternmed.2014.8063. The Women’s Health Initiative (WHI) studies
Rossouw JE et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal
women: principal results From the Women\'s Health Initiative randomized controlled trial. JAMA.
2002 Jul 17;288(3):321-33. doi: 10.1001/jama.288.3.321.
Anderson GL et al. Effects of conjugated equine estrogen in postmenopausal women with
hysterectomy: the Women\'s Health Initiative randomized controlled trial. JAMA. 2004 Apr
14;291(14):1701-12. doi: 10.1001/jama.291.14.1701.
Decline in HRT after WHI studies
Sprague BL, Trentham-Dietz A, Cronin KA. A sustained decline in postmenopausal hormone
use: results from the National Health and Nutrition Examination Survey, 1999-2010. Obstet
Gynecol. 2012 Sep;120(3):595-603. doi: 10.1097/AOG.0b013e318265df42.
Danish Osteoporosis Prevention Study Schierbeck LL metal. Effect of hormone replacement therapy on cardiovascular events in
recently postmenopausal women: randomised trial. BMJ. 2012 Oct 9;345:e6409. doi:
10.1136/bmj.e6409.
Kronos Early Estrogen Prevention Study (KEEPS)
Harman SM, et al. Arterial imaging outcomes and cardiovascular risk factors in recently
menopausal women: a randomized trial. Ann Intern Med. 2014 Aug 19;161(4):249-60. doi:
10.7326/M14-0353.
Kronos Early Estrogen Prevention Study (KEEPS)
Hodis HN et al. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.
N Engl J Med. 2016 Mar 31;374(13):1221-31. doi: 10.1056/NEJMoa1505241.
Stopping hormonal therapy
Berman RS et al. Risk factors associated with women\'s compliance with estrogen replacement
therapy. J Womens Health. 1997 Apr;6(2):219-26. doi: 10.1089/jwh.1997.6.219.
Grady D, Sawaya GF. Discontinuation of postmenopausal hormone therapy. Am J Med. 2005
Dec 19;118 Suppl 12B:163-5. doi: 10.1016/j.amjmed.2005.09.051.
Tapering vs. abrupt stop or hormonal therapy
Haimov-Kochman R et al. Gradual discontinuation of hormone therapy does not prevent the
reappearance of climacteric symptoms: a randomized prospective study. Menopause. 2006
May-Jun;13(3):370-6. doi: 10.1097/01.gme.0000186663.36211.c0. PMID: 16735933.
Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE Email us your questions at [email protected]. Assistant researcher: Aigul Zaripova, MD
Editor: Robyn Flynn
Theme music: “Fall of the Ocean Queen“ by Joseph Hackl
Rod of Asclepius designed by Kamil J. Przybos Chris’ book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-
cancer Obviously, I’m not your doctor (probably). This podcast is not medical advice for you; it is what
we call information. References: Geographic variability of menopausal symptoms
1) Nappi RE et al. Global cross-sectional survey of women with vasomotor symptoms
associated with menopause: prevalence and quality of life burden. Menopause. 2021 May
24;28(8):875-882. doi: 10.1097/GME.0000000000001793.
2) Nappi RE, et al. Prevalence and quality-of-life burden of vasomotor symptoms associated
with menopause: A European cross-sectional survey. Maturitas. 2023 Jan;167:66-74. doi:
10.1016/j.maturitas.2022.09.006.
What’s the normal duration of symptoms
3) Avis NE, et al. Study of Women\'s Health Across the Nation. Duration of menopausal
vasomotor symptoms over the menopause transition. JAMA Intern Med. 2015 Apr;175(4):531-9.
doi: 10.1001/jamainternmed.2014.8063. The Women’s Health Initiative (WHI) studies
Rossouw JE et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal
women: principal results From the Women\'s Health Initiative randomized controlled trial. JAMA.
2002 Jul 17;288(3):321-33. doi: 10.1001/jama.288.3.321.
Anderson GL et al. Effects of conjugated equine estrogen in postmenopausal women with
hysterectomy: the Women\'s Health Initiative randomized controlled trial. JAMA. 2004 Apr
14;291(14):1701-12. doi: 10.1001/jama.291.14.1701.
Decline in HRT after WHI studies
Sprague BL, Trentham-Dietz A, Cronin KA. A sustained decline in postmenopausal hormone
use: results from the National Health and Nutrition Examination Survey, 1999-2010. Obstet
Gynecol. 2012 Sep;120(3):595-603. doi: 10.1097/AOG.0b013e318265df42.
Danish Osteoporosis Prevention Study Schierbeck LL metal. Effect of hormone replacement therapy on cardiovascular events in
recently postmenopausal women: randomised trial. BMJ. 2012 Oct 9;345:e6409. doi:
10.1136/bmj.e6409.
Kronos Early Estrogen Prevention Study (KEEPS)
Harman SM, et al. Arterial imaging outcomes and cardiovascular risk factors in recently
menopausal women: a randomized trial. Ann Intern Med. 2014 Aug 19;161(4):249-60. doi:
10.7326/M14-0353.
Kronos Early Estrogen Prevention Study (KEEPS)
Hodis HN et al. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.
N Engl J Med. 2016 Mar 31;374(13):1221-31. doi: 10.1056/NEJMoa1505241.
Stopping hormonal therapy
Berman RS et al. Risk factors associated with women\'s compliance with estrogen replacement
therapy. J Womens Health. 1997 Apr;6(2):219-26. doi: 10.1089/jwh.1997.6.219.
Grady D, Sawaya GF. Discontinuation of postmenopausal hormone therapy. Am J Med. 2005
Dec 19;118 Suppl 12B:163-5. doi: 10.1016/j.amjmed.2005.09.051.
Tapering vs. abrupt stop or hormonal therapy
Haimov-Kochman R et al. Gradual discontinuation of hormone therapy does not prevent the
reappearance of climacteric symptoms: a randomized prospective study. Menopause. 2006
May-Jun;13(3):370-6. doi: 10.1097/01.gme.0000186663.36211.c0. PMID: 16735933.
